Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region
Abstract Cystine-knot peptides (CKPs) are naturally occurring peptides that exhibit exceptional chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a scaffold to construct phage-displayed CKP libraries and subsequently screened these collections against HTRA1, a...
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| Principais autores: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2024-05-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-024-48655-w |
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