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Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin

Summary: Heterologous expression of a biosynthesis gene cluster from Amycolatopsis sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of cancer cells, while having no such effect on the normal cells. Detailed...

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Principais autores: Jaime Felipe Guerrero-Garzón, Eva Madland, Martin Zehl, Madhurendra Singh, Shiva Rezaei, Finn L. Aachmann, Gaston Courtade, Ernst Urban, Christian Rückert, Tobias Busche, Jörn Kalinowski, Yan-Ru Cao, Yi Jiang, Cheng-lin Jiang, Galina Selivanova, Sergey B. Zotchev
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-12-01
Serier:iScience
Fag:
Biological Sciences
Biochemistry
Microbiology
Biotechnology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004220309822
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