RANKL/RANK/MMP-1 molecular triad contributes to the metastatic phenotype of breast and prostate cancer cells in vitro.

The osteolytic nature of bone metastasis results from a tumor-driven increased bone resorption. Bone remodeling is orchestrated by the molecular triad RANK-RANKL-OPG. This process is dysregulated in bone metastases, mostly via induction of RANKL by tumor-derived factors. These factors increase expre...

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Váldodahkkit:	Sandra Casimiro, Khalid S Mohammad, Ricardo Pires, Joana Tato-Costa, Irina Alho, Rui Teixeira, António Carvalho, Sofia Ribeiro, Allan Lipton, Theresa A Guise, Luis Costa
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Public Library of Science (PLoS) 2013-01-01
Ráidu:	PLoS ONE
Liŋkkat:	http://europepmc.org/articles/PMC3656033?pdf=render
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