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Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling

Abstract Chromogranin A (CgA), a neuroendocrine pro-hormone, is proteolytically cleaved into bioactive peptides, most notably catestatin (CST) and pancreastatin (PST), which exert opposing effects on metabolic and inflammatory processes. Using CgA- and CST knockout (KO) mice, we investigated the rol...

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Príomhchruthaitheoirí: Elke M. Muntjewerff, Dali Epremidze, Mariya Nezhyva, Satadeepa Kal, Theresa V. Rohm, Kechun Tang, Kailash Singh, Daniel Espes, Suborno Jati, Marleen Bootsma, Atef Mahmoud Mannaa, Hiromi Ikebuchi, Anna M. Nilsson, Mahadevan Rajasekaran, Per E. Andrén, Erik T. Jansson, Sushil K. Mahata, Gustaf Christoffersson
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2025-11-01
Sraith:Communications Biology
Rochtain ar líne:https://doi.org/10.1038/s42003-025-09135-z
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