Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling

Abstract Chromogranin A (CgA), a neuroendocrine pro-hormone, is proteolytically cleaved into bioactive peptides, most notably catestatin (CST) and pancreastatin (PST), which exert opposing effects on metabolic and inflammatory processes. Using CgA- and CST knockout (KO) mice, we investigated the rol...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Elke M. Muntjewerff, Dali Epremidze, Mariya Nezhyva, Satadeepa Kal, Theresa V. Rohm, Kechun Tang, Kailash Singh, Daniel Espes, Suborno Jati, Marleen Bootsma, Atef Mahmoud Mannaa, Hiromi Ikebuchi, Anna M. Nilsson, Mahadevan Rajasekaran, Per E. Andrén, Erik T. Jansson, Sushil K. Mahata, Gustaf Christoffersson
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-11-01
Serier:	Communications Biology
Online adgang:	https://doi.org/10.1038/s42003-025-09135-z
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!