Novel proteomics and neuropathology of NOTCH2NLC-related neuronal intranuclear inclusion disease

BackgroundNucleotide repeat expansion disorders constitute a group of clinically and genetically heterogeneous diseases, pathologically characterized by the misfolding, aggregation, and accumulation of proteins. The expanded GGC repeats in the 5′ untranslated region (5’UTR) of the NOTCH2NLC gene tra...

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Detalhes bibliográficos

Principais autores:	Feixia Zhan, Jiaxin Zhu, Yang Wang, Yuwen Cao, Xiya Shen, Wenlu Lv, Jiewei Wei, Xiaojun Huang, Steven X. Hou, Xinghua Luan, Li Cao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-07-01
coleção:	Frontiers in Aging Neuroscience
Assuntos:	neuronal intranuclear inclusion disease neuropathology NOTCH2NLC gene protein aggregation proteomic
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnagi.2026.1827292/full
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