Novel proteomics and neuropathology of NOTCH2NLC-related neuronal intranuclear inclusion disease

BackgroundNucleotide repeat expansion disorders constitute a group of clinically and genetically heterogeneous diseases, pathologically characterized by the misfolding, aggregation, and accumulation of proteins. The expanded GGC repeats in the 5′ untranslated region (5’UTR) of the NOTCH2NLC gene tra...

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Autori principali:	Feixia Zhan, Jiaxin Zhu, Yang Wang, Yuwen Cao, Xiya Shen, Wenlu Lv, Jiewei Wei, Xiaojun Huang, Steven X. Hou, Xinghua Luan, Li Cao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-07-01
Serie:	Frontiers in Aging Neuroscience
Soggetti:	neuronal intranuclear inclusion disease neuropathology NOTCH2NLC gene protein aggregation proteomic
Accesso online:	https://www.frontiersin.org/articles/10.3389/fnagi.2026.1827292/full
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