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Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors

A new type of berberine derivatives was obtained by the reaction of berberrubine with aliphatic sulfonyl chlorides. The new polycyclic compounds have a sultone ring condensed to <i>C</i> and <i>D</i> rings of a protoberberine core. The reaction conditions were developed to facilitate the formation o...

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Sparad:
Huvudupphov: Elizaveta D. Gladkova, Arina A. Chepanova, Ekaterina S. Ilina, Alexandra L. Zakharenko, Jóhannes Reynisson, Olga A. Luzina, Konstantin P. Volcho, Olga I. Lavrik, Nariman F. Salakhutdinov
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2021-03-01
Serie:Molecules
Ämnen:
berberine
berberrubine
cancer
Tdp1 inhibitor
DNA repair enzyme
SAR
Länkar:https://www.mdpi.com/1420-3049/26/7/1945
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