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Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 Inhibitors

Protein arginine methyltransferase 5 (PRMT5) is an attractive molecular target in anticancer drug discovery due to its extensive involvement in transcriptional control, RNA processing, and other cellular pathways that are causally related to tumor initiation and progression. In recent years, various...

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Principais autores: Tyler Brown, Mengtong Cao, Y. George Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-06-01
coleção:Molecules
Assuntos:
epigenetics
arginine methylation
PRMT5
click chemistry
inhibitor
SAM analog
Acesso em linha:https://www.mdpi.com/1420-3049/27/12/3779
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