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7β-Hydroxysteroid dehydratase Hsh3 eliminates the 7-hydroxy group of the bile salt ursodeoxycholate during degradation by Sphingobium sp. strain Chol11 and other Sphingomonadaceae

ABSTRACT Bile salts are steroids with distinctive hydroxylation patterns that are produced and excreted by vertebrates. In contrast to common human bile salts, ursodeoxycholate (UDCA) has a 7-hydroxy group in β-configuration and is used in large amounts for the treatment of diverse gastrointestinal...

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Principais autores: Phil Richtsmeier, Ruslan Nedielkov, Malte Haring, Onur Yücel, Lea Elsner, Rebekka Herdis Lülf, Lars Wöhlbrand, Ralf Rabus, Heiko Moeller, Bodo Philipp, Franziska Maria Mueller
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-06-01
Serier:Applied and Environmental Microbiology
Fag:
ursodeoxycholate
steroid degradation
steroid transformation
hydroxysteroid dehydratase
Online adgang:https://journals.asm.org/doi/10.1128/aem.00185-25
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