7β-Hydroxysteroid dehydratase Hsh3 eliminates the 7-hydroxy group of the bile salt ursodeoxycholate during degradation by Sphingobium sp. strain Chol11 and other Sphingomonadaceae

ABSTRACT Bile salts are steroids with distinctive hydroxylation patterns that are produced and excreted by vertebrates. In contrast to common human bile salts, ursodeoxycholate (UDCA) has a 7-hydroxy group in β-configuration and is used in large amounts for the treatment of diverse gastrointestinal...

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Autori principali:	Phil Richtsmeier, Ruslan Nedielkov, Malte Haring, Onur Yücel, Lea Elsner, Rebekka Herdis Lülf, Lars Wöhlbrand, Ralf Rabus, Heiko Moeller, Bodo Philipp, Franziska Maria Mueller
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2025-06-01
Serie:	Applied and Environmental Microbiology
Soggetti:	ursodeoxycholate steroid degradation steroid transformation hydroxysteroid dehydratase
Accesso online:	https://journals.asm.org/doi/10.1128/aem.00185-25
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