Platelet Rich Plasma and Adipose-Derived Mesenchymal Stem Cells Mitigate Methotrexate-Induced Nephrotoxicity in Rat via Nrf2/Pparγ/HO-1 and NF-Κb/Keap1/Caspase-3 Signaling Pathways: Oxidative Stress and Apoptosis Interplay

Background: the nephrotoxicity of methotrexate (MTX) is observed in high-dose therapy. Moreover, low-dose MTX therapy for rheumatic diseases is debatable and claimed to cause renal impairment. This study aimed at studying the effect of methotrexate in repeated low doses on rat kidneys and assessing...

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Hauptverfasser:	Farooq A. Wani, Mahrous A. Ibrahim, Shimaa H. Ameen, Amira E. Farage, Zinab Abd-Elhady Ali, Khaldoon Saleh, Medhat M. Farag, Mohammed U. Sayeed, Muhannad A. Y. Alruwaili, Abdulsalam H. F. Alruwaili, Ahmad Z. A. Aljared, Rania A. Galhom
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-04-01
Schriftenreihe:	Toxics
Schlagworte:	nephrotoxicity PCR methotrexate caspase-3 MSCs apoptosis
Online-Zugang:	https://www.mdpi.com/2305-6304/11/5/398
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