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Platelet Rich Plasma and Adipose-Derived Mesenchymal Stem Cells Mitigate Methotrexate-Induced Nephrotoxicity in Rat via Nrf2/Pparγ/HO-1 and NF-Κb/Keap1/Caspase-3 Signaling Pathways: Oxidative Stress and Apoptosis Interplay

Background: the nephrotoxicity of methotrexate (MTX) is observed in high-dose therapy. Moreover, low-dose MTX therapy for rheumatic diseases is debatable and claimed to cause renal impairment. This study aimed at studying the effect of methotrexate in repeated low doses on rat kidneys and assessing...

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Principais autores: Farooq A. Wani, Mahrous A. Ibrahim, Shimaa H. Ameen, Amira E. Farage, Zinab Abd-Elhady Ali, Khaldoon Saleh, Medhat M. Farag, Mohammed U. Sayeed, Muhannad A. Y. Alruwaili, Abdulsalam H. F. Alruwaili, Ahmad Z. A. Aljared, Rania A. Galhom
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-04-01
coleção:Toxics
Assuntos:
nephrotoxicity
PCR
methotrexate
caspase-3
MSCs
apoptosis
Acesso em linha:https://www.mdpi.com/2305-6304/11/5/398
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