Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

ABSTRACT Pancreatic neuroendocrine tumors (PanNETs) frequently exhibit loss or reduced expression of the tumor suppressor MEN1, a key regulator of tumor progression and DNA damage response (DDR). However, the upstream mechanisms driving MEN1 silencing remain unclear. Here, a pooled epigenetic CRISPR...

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Hlavní autoři:	Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-07-01
Edice:	Advanced Science
Témata:	DNA damage response MEN1 pancreatic neuroendocrine tumors radiotherapy SIRT7
On-line přístup:	https://doi.org/10.1002/advs.202519824
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