Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70

Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HSP70s due to the flexible and hydrophilic nature of...

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Principais autores:	Suzanne O’Connor, Yann-Vaï Le Bihan, Isaac M. Westwood, Manjuan Liu, Oi Wei Mak, Gabriel Zazeri, Ana P. R. Povinelli, Alan M. Jones, Rob van Montfort, Jóhannes Reynisson, Ian Collins
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2022-01-01
叢編:	Molecules
主題:	HSP70 cryptic pocket fragment screen virtual screen molecular dynamics
在線閱讀:	https://www.mdpi.com/1420-3049/27/3/817
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