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Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70

Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HSP70s due to the flexible and hydrophilic nature of...

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Principais autores: Suzanne O’Connor, Yann-Vaï Le Bihan, Isaac M. Westwood, Manjuan Liu, Oi Wei Mak, Gabriel Zazeri, Ana P. R. Povinelli, Alan M. Jones, Rob van Montfort, Jóhannes Reynisson, Ian Collins
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-01-01
coleção:Molecules
Assuntos:
HSP70
cryptic pocket
fragment screen
virtual screen
molecular dynamics
Acesso em linha:https://www.mdpi.com/1420-3049/27/3/817
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