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Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species

Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during cancer treatment. Antioxidant supplements are becoming popular additions to our diet, particularly glutathione derivativ...

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Main Authors: Blanca Cucarull, Anna Tutusaus, Tania Hernáez-Alsina, Pablo García de Frutos, María Reig, Anna Colell, Montserrat Marí, Albert Morales
Format: Artigo
Language:Inglês
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
chemotherapy
oxidative stress
glutathione
superoxide
BCL-2
hepatocellular carcinoma
Online Access:https://www.mdpi.com/2076-3921/10/9/1336
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