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Molecular background of Philadelphia chromosome dependent enhancement of cellular growth and tyrosine kinase inhibitor sensitivity

Abstract The Philadelphia chromosome is the result of a balanced reciprocal translocation between the long arms of chromosomes 9 and 22, resulting in the fusion gene BCR-ABL1. Despite it being a hallmark of acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML) and mixed-phenotype acute...

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Principais autores: Md Faruq Hossain, Lisa Hagenau, Lars R. Jensen, Johannes Rhode, Thomas Sura, Manuela G. Salazar, Ana Tzvetkova, Corinna Jensen, Stephanie Edwards, Heiko Dunkel, Stefan Simm, Josefine Radke, Andreas W. Kuss
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-02-01
Serier:Experimental Hematology & Oncology
Fag:
Philadelphia chromosome
ALL
CRISPR/Cas9
BCR-ABL1 p190
TKI sensitivity
Gene expression
Online adgang:https://doi.org/10.1186/s40164-026-00758-4
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