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Molecular background of Philadelphia chromosome dependent enhancement of cellular growth and tyrosine kinase inhibitor sensitivity

Abstract The Philadelphia chromosome is the result of a balanced reciprocal translocation between the long arms of chromosomes 9 and 22, resulting in the fusion gene BCR-ABL1. Despite it being a hallmark of acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML) and mixed-phenotype acute...

Ful tanımlama

Kaydedildi:
Asıl Yazarlar: Md Faruq Hossain, Lisa Hagenau, Lars R. Jensen, Johannes Rhode, Thomas Sura, Manuela G. Salazar, Ana Tzvetkova, Corinna Jensen, Stephanie Edwards, Heiko Dunkel, Stefan Simm, Josefine Radke, Andreas W. Kuss
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2026-02-01
Seri Bilgileri:Experimental Hematology & Oncology
Konular:
Philadelphia chromosome
ALL
CRISPR/Cas9
BCR-ABL1 p190
TKI sensitivity
Gene expression
Online Erişim:https://doi.org/10.1186/s40164-026-00758-4
Etiketler: Etiketle
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