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Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements[S]

The 3′untranslated region (UTR) of human LDL receptor (LDLR) mRNA contains three AU-rich elements (AREs) responsible for rapid mRNA turnover and mediates the stabilization induced by berberine (BBR). However, the identities of the specific RNA binding proteins involved in the regulation of LDLR mRNA...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Hai Li, Wei Chen, Yue Zhou, Parveen Abidi, Orr Sharpe, William H. Robinson, Fredric B. Kraemer, Jingwen Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2009-05-01
Schriftenreihe:Journal of Lipid Research
Schlagworte:
3′untranslated region
berberine
mRNA stability
hypercholesterolemia
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S0022227520308348
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