Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications

Abstract Background Hepatocellular carcinoma (HCC) remains a global health burden, with disproportionately high mortality in China’s Guangxi region, where endemic Clonorchis sinensis (C. sinensis) infection coincides with elevated HCC incidence. Preliminary single-cell sequencing revealed marked ove...

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Hauptverfasser:	Wen-Min Lu, Jin Yan, Zhao-Ji Liu, Yong Wu, Qian-Ru Cui, Ji Feng, Yu Chen, Guang-Zhi Zhu, Tao Peng, Jing Zhou, Guo-Dong Lu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-08-01
Schriftenreihe:	Parasites & Vectors
Schlagworte:	Hepatocellular carcinoma Clonorchis sinensis CD24 E2F1 Tumor promotion
Online-Zugang:	https://doi.org/10.1186/s13071-025-06979-6
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