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Modulation of the activity of cytosolic phospholipase A2α (cPLA2α) by cellular sphingolipids and inhibition of cPLA2α by sphingomyelin[S]

We examined the effect of the cellular sphingolipid level on the release of arachidonic acid (AA) and activity of cytosolic phospholipase A2α (cPLA2α) using two Chinese hamster ovary (CHO)-K1-derived mutants deficient in sphingolipid synthesis: LY-B cells defective in the LCB1 subunit of serine palm...

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Principais autores: Hiroyuki Nakamura, Shigeo Wakita, Akiko Suganami, Yutaka Tamura, Kentaro Hanada, Toshihiko Murayama
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2010-04-01
coleção:Journal of Lipid Research
Assuntos:
arachidonic acid
glycerophospholipids
Chinese hamster ovary cells
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S002222752030482X
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