Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling

Poor bone quality contributes to bone fragility in diabetes, aging, and osteogenesis imperfecta. However, the mechanisms controlling bone quality are not well understood, contributing to the current lack of strategies to diagnose or treat bone quality deficits. Transforming growth factor beta (TGF-β...

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主要な著者:	Neha S. Dole, Courtney M. Mazur, Claire Acevedo, Justin P. Lopez, David A. Monteiro, Tristan W. Fowler, Bernd Gludovatz, Flynn Walsh, Jenna N. Regan, Sara Messina, Daniel S. Evans, Thomas F. Lang, Bin Zhang, Robert O. Ritchie, Khalid S. Mohammad, Tamara Alliston
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2017-11-01
シリーズ:	Cell Reports
主題:	osteocyte TGF-β bone quality perilacunar/canalicular remodeling bone fragility
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124717315954
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