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Unravelling inclusion body myositis using a patient‐derived fibroblast model

Abstract Background Inclusion body myositis (IBM) is an inflammatory myopathy clinically characterized by proximal and distal muscle weakness, with inflammatory infiltrates, rimmed vacuoles and mitochondrial changes in muscle histopathology. There is scarce knowledge on IBM aetiology, and non‐establ...

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Principais autores: Judith Cantó‐Santos, Laura Valls‐Roca, Ester Tobías, Francesc Josep García‐García, Mariona Guitart‐Mampel, Anna Esteve‐Codina, Beatriz Martín‐Mur, Mercedes Casado, Rafael Artuch, Estel Solsona‐Vilarrasa, José Carlos Fernandez‐Checa, Carmen García‐Ruiz, Carles Rentero, Carlos Enrich, Pedro J. Moreno‐Lozano, José César Milisenda, Francesc Cardellach, Josep M. Grau‐Junyent, Glòria Garrabou
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2023-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Assuntos:
Inclusion body myositis
Myopathy
Fibroblasts
Autophagy
Inflammation
Mitochondria
Acceso en liña:https://doi.org/10.1002/jcsm.13178
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