Large language model-guided CAR-T in silico platform for cytokine optimization in liver cancer with low antigen density
Abstract CAR-T cell therapy has shown remarkable success in hematologic malignancies but remains limited in solid tumors such as liver cancer due to antigen heterogeneity, low target antigen density, and an immunosuppressive tumor microenvironment (TME). Cytokine engineering can enhance CAR-T persis...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BMC
2026-07-01
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| Col·lecció: | Journal of Hematology & Oncology |
| Matèries: | |
| Accés en línia: | https://doi.org/10.1186/s13045-026-01822-6 |
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