Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression

BackgroundTraumatic and thermal injuries result in a state of systemic immune suppression, yet the mechanisms that underlie its development are poorly understood. Released from injured muscle and lysed red blood cells, heme is a damage associated molecular pattern with potent immune modulatory prope...

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Bibliografiska uppgifter

Huvudupphov:	Sebastian Tullie, Thomas Nicholson, Jonathan R. B. Bishop, Kirsty C. McGee, Ali Asiri, Jack Sullivan, Yung-Yi Chen, Amanda V. Sardeli, Antonio Belli, Paul Harrison, Naiem S. Moiemen, Janet M. Lord, Jon Hazeldine
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2024-06-01
Serie:	Frontiers in Immunology
Ämnen:	burns critical care heme immune suppression trauma
Länkar:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1416820/full
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