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Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression

BackgroundTraumatic and thermal injuries result in a state of systemic immune suppression, yet the mechanisms that underlie its development are poorly understood. Released from injured muscle and lysed red blood cells, heme is a damage associated molecular pattern with potent immune modulatory prope...

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Principais autores: Sebastian Tullie, Thomas Nicholson, Jonathan R. B. Bishop, Kirsty C. McGee, Ali Asiri, Jack Sullivan, Yung-Yi Chen, Amanda V. Sardeli, Antonio Belli, Paul Harrison, Naiem S. Moiemen, Janet M. Lord, Jon Hazeldine
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-06-01
Serier:Frontiers in Immunology
Fag:
burns
critical care
heme
immune suppression
trauma
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1416820/full
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