Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia–Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis

Abstract Hepatic ischemia–reperfusion (IR) injury remains a common issue lacking effective strategy and validated pharmacological targets. Here, using an unbiased metabolomics screen, this study finds that following murine hepatic IR, liver 3‐hydroxyanthranilic acid (3‐HAA) and quinolinic acid (QA)...

Descripción completa

Detalles Bibliográficos

Autores principales:	Bowen Xu, Peng Zhang, Xiaolong Tang, Shiguan Wang, Jing Shen, Yuanwen Zheng, Chao Gao, Ping Mi, Cuijuan Zhang, Hui Qu, Shiyang Li, Detian Yuan
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2022-12-01
Colección:	Advanced Science
Materias:	hepatic ischemia–reperfusion kynurenine pathway metabolic rewiring nicotinamide adenine dinucleotide (NAD) redox
Acceso en línea:	https://doi.org/10.1002/advs.202204697
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!