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Exploration of potential mechanisms and biomarkers related to ERS-associated RCD in steroid-induced osteonecrosis of the femoral head based on bioinformatics, with experimental validation

BackgroundThe pathogenesis of osteonecrosis of the femoral head (ONFH) is associated with endoplasmic reticulum stress (ERS) and regulated cell death (RCD), but reliable linking biomarkers and their mechanisms remain unclear. This study aimed to screen SONFH biomarkers related to ERS/RCD and explore...

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Principais autores: Chengbin Yang, Tiansen Zhao, Junhao Xie, Xiangyi Luo, Xiang Tai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Endocrinology
Assuntos:
bioinformatics
biomarker
endoplasmic reticulum stress
osteonecrosis of the femoral head
regulated cell death
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fendo.2026.1734283/full
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