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TLR2 and IRF8 are the biomarkers associated with hypoxia in steroid-induced osteonecrosis of the femoral head via bioinformatics analysis and experimental validation

Abstract Background Accumulating evidence has shown that hypoxia harbors a dominant role in pathophysiological mechanisms of steroid-induced osteonecrosis of the femoral head (SONFH), but the significance of hypoxia in SONFH is still rarely explored. Methods By integrating SONFH gene expression matr...

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Principais autores: Jing Zhang, Junfang Wang, Jing Guo, Biaofang Wei
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-09-01
Serier:BMC Musculoskeletal Disorders
Fag:
Steroid-induced osteonecrosis of the femoral head
Hypoxia
Bioinformatics
TLR2
IRF8
Online adgang:https://doi.org/10.1186/s12891-025-09132-7
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