Ligands binding diffusively to protein target act as inhibitors of protein-protein interactions.

Nuclear localization signal (NLS) sequence from capsid protein of Venezuelan equine encephalitis virus (VEEV) binds to importin-α transport protein and clogs nuclear import. Prevention of viral NLS binding to importin-α may represent a viable therapeutic route. Here, we investigate the molecular mec...

Descrición completa

Detalles Bibliográficos

Principais autores:	William Jeffries, Bryan M Delfing, Xavier E Laracuente, Xingyu Luo, Audrey Olson, Kenneth W Foreman, Kyung Hyeon Lee, Greg Petruncio, Vito De Benedictis, Mikell Paige, Kylene Kehn-Hall, Christopher Lockhart, Dmitri K Klimov
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2025-09-01
Series:	PLoS Computational Biology
Acceso en liña:	https://doi.org/10.1371/journal.pcbi.1013495
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!