Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation

Chronic hepatotropic viral infections are characterized by exhausted CD8+ T cells in the presence of cognate antigen in the liver. The impairment of T cell response limits the control of chronic hepatotropic viruses. Immune-modulatory strategies are attractive options to re-invigorate exhausted T ce...

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Autores principales:	Kingsley Gideon Kumashie, Marcin Cebula, Claudia Hagedorn, Florian Kreppel, Marina C. Pils, Friedrich Koch-Nolte, Björn Rissiek, Dagmar Wirth
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-02-01
Colección:	Frontiers in Immunology
Materias:	T cell exhaustion CXCR5+ T cells CpG oligonucleotide T cell reinvigoration exhausted stem-like T cells liver resident T cells
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.592328/full
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