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Revisiting the clastosome: a stress-induced nuclear proteolytic compartment of mammalian cells

The nuclear ubiquitin proteasome system (UPS) is fundamental to maintaining proteostasis and ensuring the quality control of nuclear proteins. Within the nucleus, proteasomes are distributed throughout the nucleoplasm and can aggregate into nuclear bodies. In 2002, our group provided the first descr...

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Principais autores: Miguel Lafarga, María T. Berciano, Noemí Rueda, Sofía Cardona-Cortés, Olga Tapia
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Neuroanatomy
Fag:
cellular stress
clastosomes
down syndrome
mammalian neurons
nuclear condensates
nuclear proteolytic centers
Online adgang:https://www.frontiersin.org/articles/10.3389/fnana.2026.1839944/full
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