Reduced ZMPSTE24 expression leads to prelamin accumulation and development of steatosis in MASLD patients

Abstract Metabolic-associated steatotic liver disease (MASLD) is highly prevalent in type 2 diabetes mellitus (T2D) and its incidence has increased with the obesity epidemic. Mutations of nuclear lamina-associated genes including LMNA have been associated with fatty liver. We previously described a...

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Bibliografische Detailangaben

Hauptverfasser:	Joseph D. Schinderle, Anqi Wu, Irina M. Bochkis
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-11-01
Schriftenreihe:	Scientific Reports
Schlagworte:	MASLD Steatosis ZMPSTE24 Nuclear lamina Prelamin
Online-Zugang:	https://doi.org/10.1038/s41598-025-30052-y
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