Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases

Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents. The adenylation (A) domain is a key catalytic domain t...

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Detalhes bibliográficos

Principais autores:	Mengli Zhang, Zijing Peng, Zhenkuai Huang, Jiaqi Fang, Xinhai Li, Xiaoting Qiu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-07-01
Colecção:	Marine Drugs
Assuntos:	adenylation domain in nonribosomal peptide synthetase substrate-specificity codes of the adenylation domain interrupted adenylation domain with methylase activity nonribosomal peptide synthetase engineering targeting the adenylation domain
Acesso em linha:	https://www.mdpi.com/1660-3397/22/8/349
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