Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases

Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents. The adenylation (A) domain is a key catalytic domain t...

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Autors principals:	Mengli Zhang, Zijing Peng, Zhenkuai Huang, Jiaqi Fang, Xinhai Li, Xiaoting Qiu
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-07-01
Col·lecció:	Marine Drugs
Matèries:	adenylation domain in nonribosomal peptide synthetase substrate-specificity codes of the adenylation domain interrupted adenylation domain with methylase activity nonribosomal peptide synthetase engineering targeting the adenylation domain
Accés en línia:	https://www.mdpi.com/1660-3397/22/8/349
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