Meiotic prophase length modulates Tel1-dependent DNA double-strand break interference.
During meiosis, genetic recombination is initiated by the formation of many DNA double-strand breaks (DSBs) catalysed by the evolutionarily conserved topoisomerase-like enzyme, Spo11, in preferred genomic sites known as hotspots. DSB formation activates the Tel1/ATM DNA damage responsive (DDR) kinas...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science (PLoS)
2024-03-01
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| Col·lecció: | PLoS Genetics |
| Accés en línia: | https://doi.org/10.1371/journal.pgen.1011140 |
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