Cdk2-Null Mice Are Resistant to ErbB-2-Induced Mammary Tumorigenesis
The concept of targeting G1 cyclin-dependent kinases (CDKs) in breast cancer treatments is supported by the fact that the genetic ablation of Cdk4 had minimal impacts on normal cell proliferation in majority of cell types, resulting in near-normal mouse development, whereas such loss of Cdk4 complet...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Elsevier
2011-05-01
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| Edice: | Neoplasia: An International Journal for Oncology Research |
| On-line přístup: | http://www.sciencedirect.com/science/article/pii/S1476558611800618 |
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