SPP1+ macrophages in tumor immunosuppression: mechanisms and therapeutic implications

Secreted phosphoprotein 1 (SPP1+) macrophages are a recurrent and functionally critical immune cell subset across multiple cancer types. They drive adverse clinical outcomes by promoting immunosuppression, tumor invasion, metastasis, and therapy resistance. Given their prevalence and pivotal role, S...

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Hlavní autoři:	Juanjuan Wang, Ya Wang, Yuqing Liu, Rongcun Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-12-01
Edice:	Frontiers in Immunology
Témata:	SPP1+ macrophages T cell exhaustion physical barrier osteopontin cancer therapy
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1711015/full
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