SPP1+ macrophages in tumor immunosuppression: mechanisms and therapeutic implications

Secreted phosphoprotein 1 (SPP1+) macrophages are a recurrent and functionally critical immune cell subset across multiple cancer types. They drive adverse clinical outcomes by promoting immunosuppression, tumor invasion, metastasis, and therapy resistance. Given their prevalence and pivotal role, S...

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Bibliografische Detailangaben

Hauptverfasser:	Juanjuan Wang, Ya Wang, Yuqing Liu, Rongcun Yang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-12-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	SPP1+ macrophages T cell exhaustion physical barrier osteopontin cancer therapy
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1711015/full
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