Metformin combined with cisplatin reduces anticancer activity via ATM/CHK2-dependent upregulation of Rad51 pathway in ovarian cancer

Ovarian cancer (OC) is the deadliest malignancy of the female reproductive system. The standard first-line therapy for OC involves cytoreductive surgical debulking followed by chemotherapy based on platinum and paclitaxel. Despite these treatments, there remains a high rate of tumor recurrence and r...

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Autors principals:	Jingjing Zhang, Ping Zhou, Tiancheng Wu, Liping Zhang, Jiaqi Kang, Jing Liao, Daqiong Jiang, Zheng Hu, Zhiqiang Han, Bo Zhou
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-11-01
Col·lecció:	Neoplasia: An International Journal for Oncology Research
Matèries:	Metformin Cisplatin resistance Ovarian cancer ATM/CHK2 Rad51
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1476558624000794
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