Metformin combined with cisplatin reduces anticancer activity via ATM/CHK2-dependent upregulation of Rad51 pathway in ovarian cancer

Ovarian cancer (OC) is the deadliest malignancy of the female reproductive system. The standard first-line therapy for OC involves cytoreductive surgical debulking followed by chemotherapy based on platinum and paclitaxel. Despite these treatments, there remains a high rate of tumor recurrence and r...

Cijeli opis

Bibliografski detalji

Glavni autori:	Jingjing Zhang, Ping Zhou, Tiancheng Wu, Liping Zhang, Jiaqi Kang, Jing Liao, Daqiong Jiang, Zheng Hu, Zhiqiang Han, Bo Zhou
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2024-11-01
Serija:	Neoplasia: An International Journal for Oncology Research
Teme:	Metformin Cisplatin resistance Ovarian cancer ATM/CHK2 Rad51
Online pristup:	http://www.sciencedirect.com/science/article/pii/S1476558624000794
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!