Characterization of ESR1 alterations in patients with breast and gynecologic cancers

Abstract Background ESR1 alterations present a common mechanism of resistance to endocrine therapy (ET) in hormonally driven tumors. The clinical significance of these alterations continues to evolve with newly approved targeted therapies and a range of ongoing investigational trials. Methods A retr...

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Главные авторы:	Gargi D. Basu, Paige E. Innis, Angela K. Deem, Arthur Starodynov, Sameer S. Udhane, Szabolcs Szelinger, Min Wang, Janine R. LoBello, Frederick L. Baehner, Jean-Paul De La O, Joyce O’Shaughnessy
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2026-01-01
Серии:	Breast Cancer Research
Предметы:	Estrogen receptor Resistance Breast cancer Gynecologic cancers Comprehensive genomic profiling
Online-ссылка:	https://doi.org/10.1186/s13058-025-02217-0
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