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Characterization of ESR1 alterations in patients with breast and gynecologic cancers

Abstract Background ESR1 alterations present a common mechanism of resistance to endocrine therapy (ET) in hormonally driven tumors. The clinical significance of these alterations continues to evolve with newly approved targeted therapies and a range of ongoing investigational trials. Methods A retr...

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Principais autores: Gargi D. Basu, Paige E. Innis, Angela K. Deem, Arthur Starodynov, Sameer S. Udhane, Szabolcs Szelinger, Min Wang, Janine R. LoBello, Frederick L. Baehner, Jean-Paul De La O, Joyce O’Shaughnessy
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-01-01
Colecção:Breast Cancer Research
Assuntos:
Estrogen receptor
Resistance
Breast cancer
Gynecologic cancers
Comprehensive genomic profiling
Acesso em linha:https://doi.org/10.1186/s13058-025-02217-0
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