Distinct Virologic Properties of African and Epidemic Zika Virus Strains: The Role of the Envelope Protein in Viral Entry, Immune Activation, and Neuropathogenesis

The 2016 Zika virus (ZIKV) epidemic has largely subsided, but a key question remains. How did ZIKV evolve to become a virulent human pathogen compared to the virus of its original discovery? What specific virologic and pathologic changes contributed to increased pathogenicity in humans? Phylogenetic...

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Auteurs principaux:	Ashkan Roozitalab, Chenyu Zhang, Jiantao Zhang, Ge Li, Chengyu Yang, Wangheng Hou, Qiyi Tang, Richard Y. Zhao
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2025-07-01
Collection:	Pathogens
Sujets:	Zika virus (ZIKV) envelope (E) protein African lineage Asian lineage human neural progenitor cell (hNPC)-derived neurosphere viral entry
Accès en ligne:	https://www.mdpi.com/2076-0817/14/7/716
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