Spatial Profiles of Intratumoral PD-1+ Helper T Cells Predict Prognosis in Head and Neck Squamous Cell Carcinoma

BackgroundFunctional interactions between immune cells and neoplastic cells in the tumor immune microenvironment have been actively pursued for both biomarker discovery for patient stratification, as well as therapeutic anti-cancer targets to improve clinical outcomes. Although accumulating evidence...

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Bibliografische Detailangaben

Hauptverfasser:	Kanako Yoshimura, Takahiro Tsujikawa, Junichi Mitsuda, Hiroshi Ogi, Sumiyo Saburi, Gaku Ohmura, Akihito Arai, Saya Shibata, Guillaume Thibault, Young Hwan Chang, Daniel R. Clayburgh, Satoru Yasukawa, Aya Miyagawa-Hayashino, Eiichi Konishi, Kyoko Itoh, Lisa M. Coussens, Shigeru Hirano
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-10-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	Head and neck cancer helper T cell PD-1 tumor heterogeneity multiplex immunohistochemistry
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.769534/full
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