Collision of germline POLE and PMS2 variants in a young patient treated with immune checkpoint inhibitors

Abstract The onset of multiple and metachronous tumors in young patients induces to suspect the presence of genetic variants in genes associated with tumorigenesis. We describe here the unusual case of a 16-year-old patient who developed a synchronous bifocal colorectal adenocarcinoma with distant m...

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Detalles Bibliográficos

Principais autores:	Enrico Berrino, Roberto Filippi, Clara Visintin, Serena Peirone, Elisabetta Fenocchio, Giovanni Farinea, Franco Veglio, Massimo Aglietta, Anna Sapino, Matteo Cereda, Rosella Visintin, Barbara Pasini, Caterina Marchiò
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2022-03-01
Series:	npj Precision Oncology
Acceso en liña:	https://doi.org/10.1038/s41698-022-00258-8
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