Collision of germline POLE and PMS2 variants in a young patient treated with immune checkpoint inhibitors

Abstract The onset of multiple and metachronous tumors in young patients induces to suspect the presence of genetic variants in genes associated with tumorigenesis. We describe here the unusual case of a 16-year-old patient who developed a synchronous bifocal colorectal adenocarcinoma with distant m...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Enrico Berrino, Roberto Filippi, Clara Visintin, Serena Peirone, Elisabetta Fenocchio, Giovanni Farinea, Franco Veglio, Massimo Aglietta, Anna Sapino, Matteo Cereda, Rosella Visintin, Barbara Pasini, Caterina Marchiò
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Portfolio 2022-03-01
Σειρά:	npj Precision Oncology
Διαθέσιμο Online:	https://doi.org/10.1038/s41698-022-00258-8
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