Targeted Radiosensitization of ETS Fusion-Positive Prostate Cancer through PARP1 Inhibition

ETS gene fusions, which result in overexpression of an ETS transcription factor, are considered driving mutations in approximately half of all prostate cancers. Dysregulation of ETS transcription factors is also known to exist in Ewing's sarcoma, breast cancer, and acute lymphoblastic leukemia. We p...

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Autors principals:	Sumin Han, J Chad Brenner, Aaron Sabolch, Will Jackson, Corey Speers, Kari Wilder-Romans, Karen E Knudsen, Theodore S Lawrence, Arul M Chinnaiyan, Felix Y Feng
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2013-10-01
Col·lecció:	Neoplasia: An International Journal for Oncology Research
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1476558613801108
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