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Hypoxia/Reoxygenation-Induced Mitochondrial Reverse Electron Transfer: A Targetable Mechanism to Enhance Radiosensitivity in Non-Small Cell Lung Cancer

Hypoxia-induced radioresistance remains a major obstacle in non-small cell lung cancer (NSCLC) radiotherapy. This study investigates whether artificially activating mitochondrial reverse electron transfer (RET) can enhance radiosensitivity in NSCLC by triggering oxidative stress. An in vitro hypoxia...

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Principais autores: Cuilan Hu, Zheng Shi, Yanyu Bao, Nannan He, Xiongxiong Liu, Dan Xu, Qiang Li, Xingting Bao, Chao Sun
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-05-01
Serier:Antioxidants
Fag:
mitochondrial ROS
reverse electron transfer
oxidative stress
radiosensitization
succinate
Online adgang:https://www.mdpi.com/2076-3921/15/6/697
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